bare lymphocyte syndrome การใช้

• A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome ( BLS; MIM 209920 ).
• As a notable contrast, however, bare lymphocyte syndrome does not result in decreased B-and T-cell counts, as the development of these cells is not impaired.
• The bare lymphocyte syndrome, type II ( BLS II ) is a rare recessive genetic condition in which a group of genes called major histocompatibility complex class II ( MHC class II ) are not expressed.
• Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B . Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.
• Because many genes belonging to HLA remain unidentified, bare lymphocyte syndrome I ( BLS I ), exhibits a number of similarities with DPB in those affected, including chronic sinusitis, bronchiolar inflammation and nodules, and the presence of " H . influenzae ".